What happened: The Baltimore Orioles marked Lou Gehrig Day, saying they would play in honor of the Hall of Famer's life and legacy. The club tied the observance to its ongoing effort to raise awareness for ALS and support those affected by the disease.

Why it matters: Lou Gehrig Day is observed across MLB to remember the former Yankees great whose career was cut short by ALS, the neurodegenerative illness that now carries his name. The leaguewide tribute keeps research funding and patient support in the spotlight during the regular season.

What to watch: Expect continued ALS-awareness activations from the Orioles and other clubs as the leaguewide Lou Gehrig Day observance plays out.