What happened: His absence leaves Kirk Cousins and Fernando Mendoza as Las Vegas' top two quarterbacks for the AFC West matchup at SoFi Stadium. O'Connell had been the Raiders' emergency third quarterback in the season-opening win over the Dolphins.

Why it matters: The change strips away experienced depth before the Raiders' first divisional game of the season. It also leaves Mendoza one play from action in a quarterback room Las Vegas reshaped around Cousins and the rookie backup.

What to watch: Watch the Raiders' inactive list and backup plan as kickoff approaches. Any in-game change behind Cousins would move Mendoza into immediate duty.