What happened: Alabama will be without right tackle Jayvin James for Saturday's game at Mississippi State, with Pete Thamel reporting his status as out. Coach Kalen DeBoer also has Justin Hill, Desmond Umeozulu, Cayden Jones, Jorden Edmonds and Nick Sherman unavailable, while defensive back Zavier Mincey is listed as probable.

Why it matters: The absences land before a road game against a Mississippi State team that enters 4-0 and ranked No. 16. Alabama's injury list is heaviest on defense, adding pressure on Alabama in a matchup that could shape the SEC race and draw College Football Playoff attention.

What to watch: Watch Alabama's pregame depth chart at right tackle and for any late changes in the defensive rotation. Mississippi State's response to the spotlight will sharpen the next read on the SEC pecking order.