What happened: Buffalo will use Kyle Allen and Shane Buechele against Pittsburgh, while Cleveland will turn to Dillon Gabriel and Taylen Green against New England. San Francisco expects few regular starters against Las Vegas, and Los Angeles Rams rookie Ty Simpson is set to play against the Chargers.
Why it matters: San Francisco's caution comes before a shortened turnaround to its regular-season opener in Australia. Cleveland's plan gives Gabriel and Green the final game reps before roster decisions.
By the numbers: Across four highlighted matchups, six quarterbacks are confirmed to play: Kyle Allen, Shane Buechele, Dillon Gabriel, Taylen Green, Justin Herbert and Ty Simpson.
What to watch: Watch for Ashton Jeanty's game status and the Rams' final division of quarterback reps among Simpson, Stetson Bennett IV and Matthew Caldwell.