What happened: Los Angeles Chargers center Tyler Biadasz is out indefinitely after sustaining damage to his ACL and other injuries to his left knee. The lineman suffered the injury during Tuesday's joint practice session against the San Francisco 49ers.

Why it matters: Losing their starting center represents a significant setback for the Chargers' offensive line continuity. The injury forces Los Angeles to quickly reconfigure its interior protection scheme ahead of the regular season.

What to watch: Biadasz will meet with additional doctors to gain further clarity on the injury. The Chargers will need to evaluate interior line options as the preseason continues.