What happened: Adam Schefter reported Friday that Jayden Daniels, Caleb Williams and Baker Mayfield are among 16 players out for Sunday's games. The list also includes Rachaad White, Breece Hall, Adonai Mitchell, DeVonta Smith, Dallas Goedert, Terrance Ferguson, Aaron Donald, Azeez Al-Shaair, Cobie Durant, DeMarvion Overshown and Aaron Banks.

Why it matters: The quarterback absences alone reshape several Week 4 game plans, while losses at running back, tight end and receiver thin multiple offenses at once. It also closes one of the week's biggest availability questions after Daniels had still been tracked for London earlier this week.

What to watch: Sunday's official inactive lists will show whether any additional questionable players join the group before kickoff. The biggest follow is how offenses adjust behind backup quarterbacks and reshuffled skill-position rotations.