What happened: The wide receiver's designation was confirmed following his absence from Thursday's practice session. He misses a second consecutive game after sitting out Week 4 against the Rams.

Why it matters: The offense must navigate the out-of-conference matchup missing two premier targets. Saquon Barkley was previously ruled out with his own hamstring issue, heavily impacting the starting rotation.

What to watch: Coaches will rely on depth receivers to absorb the vacant target share. His recovery timeline will be updated next week.