What happened: The Philadelphia Eagles have ruled out five players, including running back Saquon Barkley and wide receiver DeVonta Smith, for Sunday's game in London against the Jacksonville Jaguars. Both offensive stars missed practice all week due to hamstring injuries.

Why it matters: The injuries leave Philadelphia's offense severely undermanned heading into Week 5. The Eagles will rely on practice squad elevations Dameon Pierce and Carson Steele in the backfield, while turning to undrafted rookie Jake Majors to start at center.

What to watch: Dallas Goedert returns to action after missing two games, providing a crucial target for Jalen Hurts in a depleted passing attack.