What happened: Philadelphia Eagles edge rusher Jonathan Greenard is officially inactive for Sunday's game against the Jacksonville Jaguars. The absence comes after the veteran was held out of practice throughout the week while managing an ankle injury.

Why it matters: The defensive front will be short-handed in London without Greenard available to generate pressure. Philadelphia's defense takes the field already missing several other key contributors.

What to watch: Rotational edge rushers will step in to fill the void against the Jacksonville offense.