What happened: Jefferson was ruled out Friday for Minnesota's game against Miami after hurting his ankle in last week's win over Tampa Bay. Charles Demmings and Brett Thorson were also ruled out, and Johnny Hekker is set to be elevated from the practice squad to handle punts.

Why it matters: Minnesota heads into Sunday without its top receiving threat, a significant change after Jefferson opened 2026 with steady production and two touchdowns in three games. The absence extends the ankle issue that already put his Week 4 status in doubt and leaves the Vikings thinner on offense and special teams.

What to watch: Sunday's inactive list will finalize Minnesota's game-day reshuffle, including Hekker's elevation. The next key marker for Jefferson will be whether he returns to practice ahead of Week 5.