What happened: The Carolina Panthers have ruled out Devin Lloyd, Claudin Cherelus and Nick Scott for Sunday. Jalen Coker and Xavier Legette are listed as questionable on the injury report.

Why it matters: Losing Lloyd, ranked No. 27 on the NFL Top 100, alters the defensive alignment. The questionable designations for Coker and Legette create further uncertainty for the offensive game plan.

What to watch: Coker and Legette's availability will be determined closer to kickoff.