What happened: Philadelphia Eagles running back Saquon Barkley is out for Sunday's game against the Jacksonville Jaguars due to a hamstring injury sustained in Week 4. He is considered week-to-week and could return for next Sunday's matchup with the Carolina Panthers.

Why it matters: Barkley's absence compounds depth issues for the 2-5 Eagles, who are also missing receivers DeVonta Smith and Hollywood Brown, center Drew Kendall, and safety Marcus Epps. With backup Tank Bigsby on injured reserve, Philadelphia signed running backs Dameon Pierce and Carson Steele from the practice squad to support Will Shipley.

What to watch: Philadelphia will monitor Barkley's practice availability ahead of the Panthers game.