What happened: Saquon Barkley will not return after sustaining a hamstring injury. The team officially downgraded him to out after initially listing him as questionable.

Why it matters: The absence leaves the backfield without its primary rusher against Los Angeles. Saquon Barkley previously required an MRI in September before returning to practice.

What to watch: Updates on the severity of the hamstring issue are expected following the conclusion of the game.