What happened: The Houston Texans have ruled out five players, including wide receiver Nico Collins and defensive end Jadeveon Clowney, for Sunday's game against the Indianapolis Colts. Linebacker Jake Hummel, offensive guard Ed Ingram, and safety M.J. Stewart will also miss the contest.

Why it matters: Collins remains sidelined after injuring his hamstring in practice last week, keeping Houston without its top receiving threat after he missed the Week 2 loss to the Cincinnati Bengals. Clowney continues to recover from a bone bruise, leaving the defense without a key starter for a second consecutive week.

What to watch: Offensive tackle Trent Brown returned to full practice on Friday but remains questionable. Houston must adjust its depth on both sides of the ball before kickoff.