What happened: San Francisco opened the practice window for defensive lineman Mykel Williams to return from the Physically Unable to Perform List. The former first-round pick opened the season on reserve/PUP.
Why it matters: San Francisco is 3-0 despite core injuries on both sides of the ball. Getting Williams back on the field gives the defensive line a first-round option as the regular season advances.
By the numbers: Mykel Williams, 2025 with San Francisco: 9 games, 20 tackles, 1 sack. Draft: 11th overall in 2025 out of Georgia. Timeline: placed on reserve/PUP on Aug. 30 after entering Week 1 as a longshot.
What to watch: Watch daily participation reports for progress toward activation to the 53-man roster.