What happened: San Francisco and Los Angeles begin their 2026 schedules Sept. 10 at 5:35 p.m. PT. The divisional matchup is the first of two this season.
Why it matters: Both teams enter 0-0, so the result establishes the first NFC West tiebreaker. Their rematch is scheduled for Week 14 in San Francisco.
By the numbers: San Francisco leads the all-time series 79-72-3 and has won 10 of the past 13 regular-season road meetings. Los Angeles won the most recent matchup 42-26 in Week 10 of 2025.
What to watch: Opening lineups and inactive lists are the next checkpoints before Thursday's kickoff.