What happened: Murley sustained a shoulder issue during a recent loss to South Africa, while Obano picked up his injury following a bench appearance against the Springboks. Emmanuel Iyogun and Chandler Cunningham-South have been called up to fill the resulting vacancies for the encounter at Everton's Hill Dickinson Stadium.

Why it matters: The double blow compounds the pressure on a squad currently enduring a five-match losing streak in the Nations Championship. With full-back George Furbank previously ruled out and Freddie Steward dealing with an ankle problem, England's backline depth is severely tested.

What to watch: Head coach Steve Borthwick is considering debuts for teenage wing Noah Caluori and newly-eligible centre Benhard Janse van Rensburg. Tom Roebuck has also arrived in camp as an additional replacement option.