What happened: The Los Angeles Chargers placed guard/tackle Trey Pipkins III on injured reserve. The team also signed quarterback DJ Uiagalelei and elevated tight end Patrick Herbert to the active roster.
Why it matters: Pipkins' move to injured reserve further depletes a Los Angeles offensive line already dealing with significant depth issues this season. The addition of Uiagalelei provides immediate quarterback depth for a struggling roster.
By the numbers: The Chargers enter the week at 1-4, averaging just 18.0 points per game while allowing 24.0 defensively. Los Angeles is a seven-point underdog in its matchup against the 5-0 Buffalo Bills.
What to watch: Los Angeles looks to snap a four-game losing streak on Sunday.