What happened: Kyler Murray and Nico Collins will not play in Week 2. Murray is sidelined by a concussion, and Collins is out with a hamstring injury. Puka Nacua is officially questionable due to a hip issue.

Why it matters: The confirmed absences remove primary playmakers from the field. Nacua's uncertain status creates additional complexity for fantasy managers finalizing their active rosters.

What to watch: Final inactive lists will confirm Nacua's availability closer to kickoff.