What happened: The Indianapolis Colts have ruled out wide receiver Alec Pierce for Week 3 due to a heel injury. He will be placed on injured reserve in the near future, sidelining him for a minimum of four weeks.

Why it matters: Pierce's absence shifts the passing attack's focus to Josh Downs, who now operates as the main target. The team prepared for this possibility earlier in the week when they added veteran Darius Slayton.

What to watch: Indianapolis must navigate the next month of the regular season without one of its key wideouts.