What happened: Baltimore Ravens quarterback Lamar Jackson was ruled out of Sunday's game against the Buffalo Bills due to a thumb injury. Jackson suffered the injury when his hand hit the arm of Buffalo defensive end Greg Rousseau during a pass attempt on Baltimore's opening offensive snap.

Why it matters: Jackson had recently returned to full practice ahead of Sunday's matchup. His departure forces Baltimore to turn to their backup quarterback while trailing Buffalo 10-7 in an in-progress contest.

What to watch: Baltimore will provide further updates on Jackson's condition following postgame medical evaluations.