What happened: Baltimore Ravens quarterback Lamar Jackson suffered a sprained ankle in Sunday's win over the Tennessee Titans and left the stadium in a walking boot. Philadelphia Eagles running back Saquon Barkley is considered week-to-week with a hamstring injury, while the Cincinnati Bengals lost Ja'Marr Chase to a concussion and Tee Higgins to an adductor issue. The Kansas City Chiefs saw Rashee Rice exit with a hamstring injury and Tyquan Thornton suffer a severe ankle injury that will sideline him 12-16 weeks.

Why it matters: The wave of injuries alters the immediate outlook for several contenders as the season enters its second month. Jackson has an 'outside' chance of playing against the Atlanta Falcons, potentially forcing Tyler Huntley into the starting role. Barkley's absence leaves the Eagles depleted in the backfield ahead of their London matchup against the Jacksonville Jaguars, especially with Tank Bigsby also headed to injured reserve.

What to watch: The Ravens will monitor Jackson's recovery leading up to Sunday's game against Atlanta. The Chiefs have reportedly reached out to Tyreek Hill's agent regarding a possible reunion to address their depleted receiving corps.