What happened: Sean McVay ruled Myles Garrett out for Week 6, confirming the edge rusher will not be activated from injured reserve. Garrett will not return to practice this week as he continues recovering from knee surgery.

Why it matters: Los Angeles acquired Garrett in a June blockbuster trade to anchor its defensive line. His continued absence stalls a defense that banked on his pass-rushing presence for a playoff push.

What to watch: Los Angeles faces Buffalo on Monday night before reevaluating Garrett's timeline for a potential return.