What happened: Houston will be without Jadeveon Clowney (knee), Nico Collins (hamstring), Jake Hummel (groin), Ed Ingram (groin) and M.J. Stewart (knee) Sunday against Indianapolis. Clowney, Collins, Hummel and Ingram did not practice this week, while Stewart was limited Wednesday and Friday around a Thursday rehab session. Offensive tackle Trent Brown returned to full participation Friday but remains questionable with knee and wrist issues.

Why it matters: Nico Collins, Houston's top wideout, injured his hamstring in practice last week and missed the Week 2 loss. Clowney's knee bone bruise keeps him sidelined for a second consecutive week.

What to watch: Kickoff against Indianapolis will clarify whether Brown is cleared, with next week's practice participation determining the timeline for the five ruled-out starters.