What happened: Kyle Shanahan ruled out wide receivers Deebo Samuel Sr. (hamstring) and Mike Evans (Achilles) and defensive lineman Nick Bosa after Friday's practice. Linebackers Garret Wallow and Luke Gifford and safety Marques Sigle will also sit, which leaves San Francisco with fewer than 48 available players for Sunday.

Why it matters: The 49ers go into Atlanta without their top two receivers and their lead pass rusher, with an unbeaten record on the line. It is another missed game for Bosa, who was also ruled out for the trip to Seattle earlier this month. Shanahan said backups may have to play roles they don't usually play: "You're always a few injuries away from those situations and now it comes down to a couple. So, percentages go up.

What to watch: Several other 49ers are listed questionable going into Sunday's kickoff in Atlanta. Watch which receivers pick up the snaps left by Samuel and Evans.