What happened: Indianapolis Colts tight end Tyler Warren is officially out for Sunday's scheduled game, per Mike Garafolo. The Colts placed Warren on their pregame inactives list after he entered the day questionable with a groin injury.

Why it matters: The pregame decision leaves the Indianapolis offense without a key tight end target in the active lineup. The injury occurred during the open portion of individual practice drills earlier in the week, per Stephen Holder.

What to watch: Indianapolis opens Sunday's scheduled regular-season contest with an adjusted tight end rotation on the active roster.