What happened: Indianapolis Colts wide receiver Alec Pierce was carted off the field Sunday night after suffering a non-contact left ankle injury against the Kansas City Chiefs. Pierce initially carried a questionable tag before being downgraded to out for the remainder of the game.

Why it matters: The setback involves the same surgically repaired ankle that caused Pierce to miss training camp. Indianapolis recently signed the wideout to a four-year, $114 million extension following a breakout 2025 campaign. Losing him removes a premier deep threat from an offense struggling during an 0-4 start to the season.

What to watch: Indianapolis will await imaging to determine if Pierce requires another stint on injured reserve.