What happened: Seattle Seahawks quarterback Sam Darnold will miss Sunday's matchup because of a quadriceps injury. Cleveland Browns quarterback Deshaun Watson remains questionable following head-injury protocol. Jacksonville Jaguars running back Bhayshul Tuten carries a questionable designation with ankle and foot ailments.

Why it matters: Seattle must turn to its reserve options under center for the upcoming contest. Cleveland and Jacksonville face game-time uncertainty at pivotal offensive skill spots as both rosters prepare for crucial conference matchups.

What to watch: Official active rosters will determine Tuten's status prior to kickoff Thu Nov 5, 8:15 PM ET. Seattle and Cleveland will provide further clarity on Darnold and Watson before the weekend.