What happened: Barring setbacks, both of San Francisco's major injury cases are expected to be available Thursday. Kickoff is scheduled for 8:35 p.m. ET.

Why it matters: The divisional matchup opens the 2026 regular season and marks the NFL's first game in Australia. The anticipated returns would reinforce both sides of San Francisco's lineup.

What to watch: Final practice participation and game-status designations will show whether that outlook holds.