What happened: Philadelphia is placing Jalen Hurts on injured reserve and sitting him out indefinitely following Saturday medical consultations over a blood clot, per ESPN's Adam Schefter and NFL Network's Ian Rapoport. Baltimore ruled Lamar Jackson out for Week 6 with an ankle injury. Chicago plans to start Caleb Williams after he returned to practice from a torn hamstring.

Why it matters: Moving Hurts to injured reserve sidelines Philadelphia's starter for at least four games during the middle of the regular season. Jackson's ankle absence leaves Baltimore without its starting quarterback for Sunday's slate, while Williams steps back into Chicago's lineup after missing three straight contests.

What to watch: Chicago will confirm Williams on the active game-day lineup ahead of Sunday kickoff, while Philadelphia and Baltimore turn to their backup quarterbacks in Week 6.