What happened: Detroit ruled out right tackle Blake Miller and left guard Christian Mahogany for Thursday's game against Buffalo. Larry Borom is listed behind Miller and Miles Frazier behind Mahogany on the unofficial depth chart. Cornerback D.J. Reed is questionable, while Christian Izien and Juice Scruggs are off the injury report.

Why it matters: The shuffle extends Detroit's offensive-line availability issues entering Buffalo and pushes Borom and Frazier into larger roles. Reed's designation leaves another late availability check in the secondary before kickoff.

What to watch: Watch Detroit's inactive list and whether Reed is cleared to go. The opening snaps will show whether Borom and Frazier get the first call up front.