What happened: The team cleared Deebo Samuel to return after staff previously ruled out Deebo Samuel Sr. against Commanders last month. Meanwhile, offensive tackle Trent Williams was designated as questionable with a shoulder ailment after limited work. Linebacker Dre Greenlaw also drew a questionable tag with a knee injury after logging 57 tackles in 2026 through 7 games.

Why it matters: San Francisco has cruised to a 7-1 start in 2026 through 8 games largely because Williams anchors the blindside and controls the line of scrimmage. While Samuel provides explosive versatility as a runner and receiver, backup playmakers can absorb touches when the blocking unit functions properly. Losing Williams destabilizes pass protection and the outside-zone ground attack, making the veteran tackle far more irreplaceable than any individual skill weapon.