What happened: Defensive end Nick Bosa returned to practice with a questionable designation due to a knee issue. Meanwhile, wide receivers Mike Evans (Achilles), Deebo Samuel Sr. (hamstring), and Christian Kirk (knee) were all ruled out for Sunday's game against Las Vegas.

Why it matters: San Francisco holds the top seed in the conference at 6-1 despite a 29-20 defeat at Atlanta in its previous game. The absences sideline Evans and Samuel, who have combined for 626 receiving yards and six touchdowns through seven weeks in 2026. Bosa's potential return bolsters the defensive front after he was limited to two appearances earlier this season.

What to watch: San Francisco faces the Las Vegas Raiders on Sunday, with Bosa's playing status to be determined before kickoff.