What happened: Henderson was hurt during Sunday's win over Las Vegas. He is expected to miss multiple weeks. He will avoid surgery, with New England hoping for a return on the shorter end of that absence.

Why it matters: Losing a starting running back for multiple October weeks tests New England's depth during the regular season. His reputation as a quick healer gives the Patriots reason to hope the absence stays short.

What to watch: New England's upcoming practice reports will show how the backfield reshapes without him.