What happened: San Francisco 49ers head coach Kyle Shanahan deemed Mykel Williams unlikely to play in the season opener due to a knee injury. The team noted the defensive end is progressing well in his recovery.

Why it matters: San Francisco is already navigating multiple edge injuries as training camp concludes. Losing last year's first-round pick removes a projected contributor from the early-season pass-rush rotation.

What to watch: Monitor practice participation reports throughout August. The team will need to finalize its defensive front if Williams remains sidelined for the opener.