What happened: San Francisco 49Ers head coach Kyle Shanahan confirmed defensive end Nick Bosa will miss multiple weeks after injuring his calf before practice. The team also ruled out rookie defensive end Romello Height for Sunday's game against the Arizona Cardinals due to hand surgery.
Why it matters: The injury creates a severe depth crisis for a defensive front that has been decimated recently. Defensive tackles C.J. West and Alfred Collins, along with defensive end Sam Okuayinonu, are on injured reserve. James Thompson Jr. is also sidelined with a high-ankle sprain.
By the numbers: Bosa played 70 snaps over the first two games of the season after returning from a torn right ACL. He previously injured his knee against the Cardinals in Week 3 of last season.
What to watch: San Francisco must decide whether to move Bosa to injured reserve, balancing his recovery timeline against the team's cap on return designations.