What happened: Bosa pulled his calf during Thursday's practice. He is out for Sunday's game against Arizona and expected to miss a few weeks, with an injured-reserve stint still under consideration.

Why it matters: Nick Bosa is a five-time Pro Bowl edge rusher and San Francisco's primary pass-rush threat. His absence further strains a defensive line already reshuffled after C.J. West landed on injured reserve and Naquan Jones was added.

What to watch: San Francisco must decide whether to place Bosa on injured reserve. His practice status next week will clarify the return timeline.