What happened: Running back Saquon Barkley, wide receiver DeVonta Smith and center Drew Kendall have been ruled out for the Philadelphia Eagles' game on Sunday in London. The absences sideline three key offensive pieces for the international matchup.

Why it matters: The injuries leave Philadelphia without significant offensive production against Jacksonville. The team must navigate the game while missing major components of its starting lineup.

What to watch: The Eagles will need to rely heavily on their offensive depth to replace the missing production on Sunday.