What happened: Running back Christian McCaffrey did not participate in Wednesday's practice due to a hamstring issue, while wide receiver Mike Evans remained out. Defensive end Nick Bosa participated on a limited basis while managing a calf injury.

Why it matters: San Francisco stands at 6-1 and aims to rebound after falling 29-20 to Atlanta in its previous outing. Preserving the health of key starters remains vital for division positioning as the Nov. 10 trade deadline approaches.

What to watch: San Francisco will release updated practice participation reports and game status designations later this week.