What happened: An ankle injury has kept TreVeyon Henderson out of practice since Aug. 24, including New England's final three sessions. Seattle ruled out Ty Okada with a hamstring injury.
Why it matters: New England loses its primary breakaway rushing threat for the Super Bowl LX rematch. Greg Van Roten, who has 105 career starts, slots in as the top interior backup behind Brown.
By the numbers: Henderson scored 10 rushing touchdowns in 2025; four covered at least 50 yards, a 40% share.
What to watch: The teams kick off Wednesday at 8:20 p.m. ET at Lumen Field. Nick Emmanwori and Tory Horton remain questionable for Seattle.