What happened: The running back injured his ankle during an Aug. 24 practice. New England traveled Monday for Wednesday night’s game in Seattle.
Why it matters: The absence removes a planned backfield option before either club has played a 2026 regular-season game. Seattle also lists Ty Okada out, with Nick Emmanwori and Tory Horton questionable.
By the numbers: The injury-to-opener gap spans 16 days, from Aug. 24 to Sept. 9.
What to watch: The Patriots’ next practice report will establish whether Henderson’s absence extends into Week 2.