What happened: Seattle Seahawks nose tackle Brandon Pili was ruled out against the Arizona Cardinals after sustaining a concussion in the first quarter. He exited early for evaluation and will not return.

Why it matters: The injury tests Seattle's depth at the primary run-stopping position, as the team is already playing without healthy scratch Mike Morris. Second-year defensive lineman Rylie Mills takes on an expanded role behind starter Byron Murphy II to contain Jeremiyah Love.

What to watch: The Seahawks must navigate the remainder of the contest with a shortened interior defensive line rotation.