What happened: League-wide expectation is that the San Francisco 49ers will respond on the trade market following the Seattle Seahawks' acquisition of six-time All-Pro guard Quenton Nelson, per Jordan Schultz. Seattle sent a 2027 third-round pick and a 2028 fifth-round pick to the Indianapolis Colts earlier Tuesday to acquire the eight-time Pro Bowler.

Why it matters: San Francisco leads the NFC West at 6-1 and holds the No. 2 seed in the conference despite a 29-20 loss at the Atlanta Falcons on Oct. 25, while Seattle sits at 4-3 as the No. 8 seed following a 20-3 win over the Kansas City Chiefs. While the Seahawks bolstered their interior line with a guard whose 85.7 PFF grade ranks second at his position, the 49ers rank 24th in the NFL in pressure rate.

What to watch: The NFL trade deadline is Nov. 10, giving the 49ers two weeks to complete a deal while the 2-5 Colts also shop defensive tackle DeForest Buckner.