What happened: The San Francisco 49ers will be without defensive end Nick Bosa for multiple weeks. The team is reportedly leaning against placing him on injured reserve because they lack available return spots.

Why it matters: Bosa's absence is a major blow to the San Francisco 49Ers defensive front. The team is already dealing with significant defensive line attrition this week.

What to watch: Watch how San Francisco manages the active roster and adjusts its pass rush without Bosa.