What happened: Washington hands the offense to backup quarterback Marcus Mariota for the morning international matchup. The passing attack faces a massive hurdle with top wideout Terry McLaurin and guard Sam Cosmi officially ruled inactive.

Why it matters: Indianapolis is dealing with similar absences, as receivers Keenan Allen and Darius Slayton sit out the contest. The lack of primary targets on both sidelines puts immense pressure on the remaining skill players to deliver.