What happened: Washington officially designated Terry McLaurin as inactive ahead of kickoff for the international series game. The roster move finalizes his status after the receiver's hamstring issue surfaced during late-week preparations.

Why it matters: The 2-4 Commanders will have to navigate the matchup without their premier passing target. Washington enters the contest listed as a against the 1-5 Colts.

What to watch: Watch how the Commanders adjust their offensive game plan and target distribution to compensate for the absence.