What happened: Defensive end Nick Bosa has been ruled out of the upcoming game against the Arizona Cardinals. Wide receiver Mike Evans is officially listed as questionable on the latest practice report.

Why it matters: The loss of Nick Bosa removes a cornerstone of the defensive front for a multi-week stretch. Evans' uncertain status leaves a question mark for the passing attack ahead of the divisional matchup.

What to watch: Final inactive lists will be released 90 minutes before kickoff to confirm whether Evans will suit up.