What happened: Los Angeles Chargers safety Derwin James experienced a setback in his recovery from a hamstring injury and could be placed on injured reserve, per NFL Network's Ian Rapoport. James has been sidelined since Sept. 27, a stretch that included missing Week 5 when the Chargers ruled him inactive.

Why it matters: An injured reserve designation would sideline the defensive captain for a minimum of four games after Los Angeles signed James to a record three-year, $75.6 million safety extension in May. His prolonged absence further depletes a winless roster coming off its bye week following a 22-6 loss at the Kansas City Chiefs on Oct. 18.

What to watch: Los Angeles will decide whether to officially place James on injured reserve ahead of its post-bye game while offensive coordinator Mike McDaniel continues calling plays and the front office weighs roster moves before the Nov. 10 NFL trade deadline.