What happened: Philadelphia Eagles quarterback Jalen Hurts is out for Sunday's game against the Carolina Panthers due to a superficial blood clot, per Ian Rapoport. Running back Saquon Barkley and wide receiver DeVonta Smith could also miss the matchup, according to Adam Schefter.

Why it matters: Philadelphia enters the Week 6 matchup potentially missing its top three offensive focal points after ruling out both Barkley and Smith for last Sunday's London loss to the Jaguars. The absences compound a depleted offense that already lost running back Will Shipley to a partial plantar fascia tear and traded center Cam Jurgens to Baltimore following right tackle Lane Johnson's retirement.

What to watch: Philadelphia will release its final injury designations for Barkley and Smith on Friday ahead of Sunday's kickoff against Carolina.