What happened: San Francisco 49ers defensive end Nick Bosa did not participate in Saturday's practice session, per Vic Tafur. Bosa is dealing with knee and calf issues after pulling his calf during a late September practice.

Why it matters: Saturday's absence casts significant doubt on Bosa's availability for Monday night's matchup against the Washington Commanders. San Francisco enters the week evaluating returning injured contributors as potential internal reinforcements ahead of the trade deadline.

What to watch: The 49ers will issue their final game-status designations before facing Washington on Monday night.